His research interests include: system identification (parameterization of systems, identifiability issues, model order reduction and model approximation); signal processing (wavelet analysis and orthogonal wavelet design, also for 2-D image processing); numerical mathematics (optimization, Lyapunov equations, large eigenvalue problems); computer algebra applications to systems theory (identifiability, global optimization, model approximation); applications of knowledge engineering to medicine and the life sciences (ECG and EEG analysis, medical image analysis, gene regulatory networks, systems biology).