He has been trained in Immunology research at National Cancer Institute (Frederick, USA) where he has conducted studies on the role of acute phase proteins and chemokines in inflammation from 1993 to 1995. He has received Fellowships from AIRC and Telethon and research grants from Telethon , Italian Health Ministry, EU 7th program and Italian, MIUR, and eRare. He is member of numerous Societies, including the Henry Kunkel Society, the European Society of Immunodeficiency, the Society of Leukocyte Biology, the Italian Society of Pediatrics, the Italian Society for Pediatric Research. He serves as Reviewer for Journal of Clinical Investigation, Blood, Journal of Immunology, Pediatric Infectious Diseaseas Journal, and is member of the Journal of Leukocyte Biology Editorial Board. He has Authored more than 100 papers on peer review Journals. He has given important contribution to the field of Primary immunodeficiencies by identification of novel diseases and providing evidence for the pathogenesis of other diseases such as WHIM syndrome and Hermansky-Pudlak syndromes.