He is internationally recognized for his current work on the mechanisms responsible for the genesis of the sleep-waking cycle, the cognitive role of sleep and the studies of sleep pathologies like narcolepsy and REM sleep behaviour disorder. In particular, he described the brainstem network responsible for generating muscle atonia during paradoxal and discover the role of MCH in generating the state. He also more recently described at cellular level the state of the cortex during paradoxical sleep showing that only a few limbic cortical structures are activated by the claustrum and the supramammillary nucleus.