Dr. Tuzcu's clinical interests cover a wide range of interventional cardiology patients. In addition to percutaneous treatment of coronary artery disease, his expertise includes catheter-based treatment of valvular heart disease (Transcatheter aortic valve replacement - TAVR), and adult congenital heart defects. He is an internationally recognized expert in the emerging field of percutaneous valve repair and replacement. Patients from all over the United States and around the world seek his expertise.
Dr. Tuzcu's current research interests focus on the investigation of catheter-based treatments for valvular heart disease. He holds several patents involving catheter design. Another long term research interest involves the use of various imaging modalities to elucidate the development and progress of atherosclerosis. He has made seminal contributions to the understanding of transplant coronary artery disease and subclinical atherosclerosis using intravascular ultrasound imaging. He had and continues to have leadership roles in landmark studies in his areas of his research interests.