Matilde Murga

10 Selected publications: 1: Murga M, Fernández-Capetillo O, Field SJ, Moreno B, Borlado LR, Fujiwara Y, Balomenos D, Vicario A, Carrera AC, Orkin SH, Greenberg ME, Zubiaga AM. Mutation of E2F2 in mice causes enhanced T lymphocyte proliferation, leading to the development of autoimmunity. Immunity. 2001 Dec;15(6):959-70. 2: Murga M, Fernandez-Capetillo O, Tosato G. Neuropilin-1 regulates attachment in human endothelial cells independently of vascular endothelial growth factor receptor-2. Blood. 2005 Mar 1;105(5):1992-9. Epub 2004 Nov 2. 3: Murga M, Jaco I, Fan Y, Soria R, Martinez-Pastor B, Cuadrado M, Yang SM, Blasco MA, Skoultchi AI, Fernandez-Capetillo O. Global chromatin compaction limits the strength of the DNA damage response. J Cell Biol. 2007 Sep 24;178(7):1101-8. 4: Toledo LI, Murga M, Gutierrez-Martinez P, Soria R, Fernandez-Capetillo O. ATR signaling can drive cells into senescence in the absence of DNA breaks. Genes Dev. 2008 Feb 1;22(3):297-302. 5: Murga M., Buenting, S., Montaña, M.F., Soria, R, Lee, Y.S., Mulero, F., Cañamero, M., McKinnon, P.J., Nussenzweig, A. and Fernandez-Capetillo, O. A mouse model of the ATR-Seckel Syndrome reveals that intrauterine exposure to replicative stress limits mammalian lifespan. Nature Genetics. 2009 Aug;41(8):891-8 6: Toledo Li, Murga M., Zur R,Soria R, Rodriguez A, Martinez S, Oyarzabal J, Pastor J, Bischoff JR, Fernandez-Capetillo O. A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations. Nat Struct Mol Biol. 2011 Jun;18(6):721-7. 7: Murga M, Campaner S, Lopez-Contreras AJ, Toledo LI, Soria R, Montaña MF, D'Artista L, Schleker T, Guerra C, Garcia E, Barbacid M, Hidalgo M, Amati B, Fernandez-Capetillo O. Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors. Nat Struct Mol Biol. 2011 Nov 27;18(12):1331-5. 8: Ruiz S, Mayor-Ruiz C, Lafarga V, Murga M, Vega-Sendino M, Ortega S, Fernandez-Capetillo O.(2016) A Genome-wide CRISPR screen identifies CDC25A as a determinant of sensitivity to ATR inhibitors. Mol Cell. Apr 21;62(2):307-13 9: Murga M, Lecona E, Kamileri I, Díaz M, Lugli N, Sotiriou SK, Anton ME, Méndez J, HalazonetisTD, Fernandez-Capetillo O. (2016) POLD3 is haploinsufficient for DNA replication in mice. Mol Cell. Sep 1;63(5):877-83. 10: Morgado-Palacin I*, Day A*, Murga M *, Lafarga V, Anton ME, Tubbs A, Chen HT, Ergan A,Anderson R, Bhandoola A, Pike KG, Barlaam B, Cadogan E, Wang X, Pierce AJ, Hubbard C,Armstrong SA, Nussenzweig A, Fernandez-Capetillo O. (*:co-authors). (2016) Targeting thekinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML. Sci Signal. 2016 Sep 13;9(445).