Research led by Professor Yacoub include tissue engineering heart valves, myocardial regeneration, novel left ventricular assist devices and wireless sensors with collaborations within Imperial College, nationally and internationally. He has also supervised over 18 higher degree (PhD/MD) students and published over 1,000 articles.

Sir Magdi has an active interest in global healthcare delivery with particular focus developing programmes in Egypt, The Gulf Region, Mozambique, Ethiopia and Jamaica. He is Founder and President of the Chain of Hope charity, treating children with correctable cardiac conditions from war-torn and developing countries and establishing training and research programmes in local cardiac units.