Kyle Hoehn

基本信息

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职业迁徙

个人简介

My lab develops novel mitochondrial uncoupler drugs for the treatment of metabolic disorders including obesity, ageing, and diabetes.

研究兴趣

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Unsymmetric Hydroxylamine and Hydrazine BAM15 Derivatives As Potent Mitochondrial Uncouplers

Joseph E. Quinlan,Joseph M. Salamoun,Christopher J. Garcia,Stefan Hargett,Martina Beretta,Riya Shrestha,Catherine Li,Kyle L. Hoehn,Webster L. Santos

BIOORGANIC & MEDICINAL CHEMISTRY (2025)

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Design, Synthesis, and Biological Evaluation of Imidazo[4,5-B]pyridine Mitochondrial Uncouplers for the Treatment of Metabolic Dysfunction-Associated Steatohepatitis (MASH)

Joseph M. Salamoun, Emily L. Krinos, Mary A. Foutz,Stefan R. Hargett,Martina Beretta,Riya Shrestha,Kyle L. Hoehn,Webster L. Santos

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY（2024）

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Corrigendum to “design, Synthesis and Biological Evaluation of Glucose Metabolism Inhibitors As Anticancer Agents” [bioorg. Chem. 151 (2024) 107665]

Yao Cheng, John Patrick Jones,Tsz Tin Yu,Ellen M. Olzomer, Jacky Su,Alice Katen,David StC Black,Gene Hart-Smith,Elizabeth S. Childress,Martina Beretta,Marc R. Wilkins, Isabel A. Mateos,Webster L. Santos,Kyle L. Hoehn,Frances L. Byrne,Naresh Kumar

Bioorganic chemistry (2024): 107725-107725

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Design, Synthesis, and Biological Evaluation of [1,2,5]Oxadiazolo[3,4-B]pyridin-7-ol As Mitochondrial Uncouplers for the Treatment of Obesity and Metabolic Dysfunction-Associated Steatohepatitis

Mary A. Foutz, Emily L. Krinos,Martina Beretta,Stefan R. Hargett,Riya Shrestha,Jacob H. Murray, Ethan Duerre,Joseph M. Salamoun, Katrina Mccarter,Divya P. Shah,Kyle L. Hoehn,Webster L. Santos

JOURNAL OF MEDICINAL CHEMISTRYno. 23 (2024): 21486-21504

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Design, Synthesis and Biological Evaluation of Glucose Metabolism Inhibitors As Anticancer Agents

Yao Cheng, John Patrick Jones,Tsz Tin Yu,Ellen M. Olzomer, Jacky Su,Alice Katen,David StC Black,Gene Hart-Smith,Elizabeth S. Childress,Marc R. Wilkins, Isabel A. Mateos,Webster L. Santos,Kyle L. Hoehn,Frances L. Byrne,Naresh Kumar

BIOORGANIC CHEMISTRY (2024)

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Beneficial Effects of MGL-3196 and BAM15 Combination in a Mouse Model of Fatty Liver Disease

Mingyan Zhou,Catherine Li,Frances L. Byrne, Calum S. Vancuylenburg,Ellen M. Olzomer,Adam Hargreaves,Lindsay E. Wu, Nicholas A. Shackel,Webster L. Santos,Kyle L. Hoehn

Acta Physiologica (2024)

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Beneficial Effects of Simultaneously Targeting Calorie Intake and Calorie Efficiency in Diet-Induced Obese Mice

Sing-Young Chen, Aiden J. Telfser,Ellen M. Olzomer, Calum S. Vancuylenberg, Mingyan Zhou,Martina Beretta,Catherine Li,Stephanie J. Alexopoulos,Nigel Turner,Frances L. Byrne,Webster L. Santos,Kyle L. Hoehn

CLINICAL SCIENCE（2024）

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Complete Inhibition of Liver Acetyl-Coa Carboxylase Activity is Required to Exacerbate Liver Tumorigenesis in Mice Treated with Diethylnitrosamine

Riya Shrestha, Calum S. Vancuylenburg,Martina Beretta, Mingyan Zhou,Divya P. Shah,Ellen M. Olzomer, Sian L. Richards,Kyle L. Hoehn,Frances L. Byrne

CANCER & METABOLISMno. 1 (2024)

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论文共 141 篇作者统计合作学者相似作者