Her main research focus is in the area of liver graft injury and cancer recurrence after transplantation utilizing an integrated basic, clinical and translational approach. She has developed a series of novel animal models to mimic liver graft injury and cancer recurrence. She is the first to establish a rat orthotopic liver transplantation model using small-for-size graft in Hong Kong. These models have been extensively introduced into the investigation of liver transplantation. For example, the correlation between transient portal hypertension resulted from excessive portal flow and hepatic sinusoidal damage of small-for-size liver graft was first revealed in animal model she established and the finding was subsequently validated in a series of her clinical studies. The further studies for the mechanism of graft injury and novel treatments were also conducted in animal models she established. She is first to report the significance of small-for-size liver graft injury on tumor recurrence after transplantation in the world and further to explore the molecular mechanisms of inflammatory response in acute phase and tumor invasiveness in late phase. In parallel, she has focused on the molecular mechanisms involved inflammation and cancer progression, together with the development of novel therapies for cancer metastasis. In addition, she has also established the research platform for in vivo small animal imaging modalities, which are widely applied in various research fields in the Faculty and beyond.