He became particularly interested in mitochondrial dynamics and neurodegeneration and relocated to the University of Sheffield to work in Dr Andy Grierson’s laboratory. There his research was focused on motor neuron diseases and the characterisation of mitochondrial axonal transport defects in models of amyotrophic lateral sclerosis (ALS) and hereditary spastic paraplegia (De Vos et al., 2007; Kasher et al., 2009). Current research themes include: The mechanisms causing defective axonal transport of mitochondria in ALS, PD and HSP. The cellular roles of the C9orf72 protein and their role in ALS and FTD The biology of close contacts between the endoplasmic reticulum (ER) and mitochondria and their involvement in health and disease