Dr. Kotloff's research focuses on the epidemiology of infectious diseases and their prevention with the use of vaccines in both the U.S. and developing countries. She is Principal Investigator (PI) of the Vaccine Treatment and Evaluation Unit (VTEU) at the UMSOM's Center for Vaccine Development and Global Health funded by the National Institute of Allergy and Infectious Disease. This contract funds vaccines and treatments against infectious diseases of public health importance. She has designed and performed many clinical trials to evaluate a wide array of vaccines, adjuvants, delivery mechanisms, and medications, in all age groups, from premature infants to the elderly, and in both healthy subjects and in those with underlying medical conditions. She has focused clinical development of vaccines and other preventive strategies for which I know the need is great, but that face challenges that have stalled the path to licensure. She has worked to find solutions to the impediments and try to advance the clinical development of these vaccines. Currently she has leadership roles in two large Phase 3 COVID-19 vaccine trials in the U.S.