Kazuaki Chayama(茶山一彰)

Professor

Department of Medicine and Molecular Science Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University

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基本信息

Career Trajectory

Bio

私たちの研究は、消化器内科の中でも肝臓病を中心とするもので、主にウイルス性肝炎や原発性肝がん、NASH（非アルコール性脂肪性肝炎）といった肝臓の病気が起こる原因を、ウイルス側と宿主であるヒトの側の遺伝子という2つの側面から探り、その治療法を見出していこうとしています。
なかでも積極的に取り組んでいるのは、難治性B型肝炎やC型肝炎、進行性肝細胞がんといった疾患です。

私たちの研究チームは、肝臓学会の最高峰であるアメリカ肝臓学会でも毎年ベスト3に入る発表数を誇っており、日本では1～2番、世界でもベスト10に入るような先進的研究チームという高い評価を得ています。

Research Interests

Papers共 2179 篇Author StatisticsCo-AuthorSimilar Experts

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Serum Uric Acid is Independently Associated with Impaired Nitroglycerine-Induced Vasodilation of the Brachial Artery in Women

Tatsuya Maruhashi,Masato Kajikawa,Shinji Kishimoto,Takayuki Yamaji,Takahiro Harada,Aya Mizobuchi,Shunsuke Tanigawa,Farina Mohamad Yusoff,Yukiko Nakano,Kazuaki Chayama,Ayumu Nakashima,Chikara Goto,Yukihito Higashi

HYPERTENSION RESEARCHno. 1 (2025): 6-14

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Modeling of Hepatitis B Virus Infection Spread in Primary Human Hepatocytes

Zhenzhen Shi,Masataka Tsuge,Nicholson Collier, Yasue Takeuchi,Takuro Uchida,Carolyn M Rutter,Yuji Teraoka,Susan Uprichard,Yuji Ishida,Chise Tateno,Jonathan Ozik,Harel Dahari,Kazuaki Chayama

bioRxiv the preprint server for biology (2025)

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Hepatitis B Virus Genotypes A1 and A2 Have Distinct Replication Phenotypes Due to Polymorphisms in the HBx Gene

Min Zhang,Karim Mouzannar,Zhensheng Zhang,Yuji Teraoka,Jason Piotrowski,Yuji Ishida, Chise Tateno-Mukaidani, Takeshi Saito,Hiromi Abe-Chayama,Kazuaki Chayama,T. Jake Liang

PLOS PATHOGENSno. 1 (2025)

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A Patient-Derived HCC Spheroid System to Model the Tumor Microenvironment and Treatment Response

Emilie Crouchet,Nuno Almeida,Sarah C. Durand,Marie Parnot,Marine A. Oudot,Fabio Giannone,Cloe Gadenne,Natascha Roehlen,Antonio Saviano,Emanuele Felli,Patrick Pessaux, Hong Tuan Duong,Hideki Ohdan,Hiroshi Aikata,Kazuaki Chayama,Thomas F. Baumert,Catherine Schuster

JHEP REPORTS（2025）

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Nationwide Survey of Patients with Acute Liver Failure and Late-Onset Hepatic Failure in Japan Seen Between 2016 and 2021

Nobuaki Nakayama,Masamitsu Nakao,Yoshihito Uchida,Akio Ido,Yasuhiro Takikawa,Keisuke Kakisaka,Naoya Kato,Kazuaki Chayama,Kazuaki Inoue,Mureo Kasahara,Shuji Terai,Hiromasa Ohira,Isao Sakaida,Taro Takami,Kiyoshi Hasegawa,Masanori Abe,Masahito Shimizu,Hitoshi Yoshiji,Takuya Genda,Ayano Inui,Ryuzo Abe,Hajime Takikawa,Atsushi Tanaka,Satoshi Mochida

Hepatology research the official journal of the Japan Society of Hepatologyno. 6 (2025): 932-947

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Deep Learning and Digital Pathology Powers Prediction of HCC Development in Steatotic Liver Disease

Takuma Nakatsuka,Ryosuke Tateishi,Masaya Sato, Natsuka Hashizume,Ami Kamada,Hiroki Nakano,Yoshinori Kabeya,Sho Yonezawa,Rie Irie,Hanako Tsujikawa,Yoshio Sumida,Masashi Yoneda,Norio Akuta,Takumi Kawaguchi,Hirokazu Takahashi,Yuichiro Eguchi,Yuya Seko,Yoshito Itoh,Eisuke Murakami,Kazuaki Chayama,Makiko Taniai,Katsutoshi Tokushige,Takeshi Okanoue,Michiie Sakamoto,Mitsuhiro Fujishiro,Kazuhiko Koike

Hepatology (Baltimore, Md)（2024）

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A PATIENT-DERIVED HEPATOCELLULAR CARCINOMA SPHEROID SYSTEM HARNESSING PATIENT SERUM TO MODEL THE TUMOR MICROENVIRONMENT AND TREATMENT RESPONSE

Emilie Crouchet,Nuno Almeida,Sarah Durand,Marie Parnot,Marine Oudot,Fabio Giannone,Cloe Gadenne,Natascha Roehlen,Antonio Saviano,Emanuele Felli,Patrick Pessaux,Hideki Ohdan,Hiroshi Aikata,Kazuaki Chayama,Thomas Baumert,Catherine Schuster

HEPATOLOGY (2024)

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An Atlas of the Human Liver Diurnal Transcriptome and Its Perturbation by Hepatitis C Virus Infection

Atish Mukherji,Frank Jühling,Yogy Simanjuntak,Emilie Crouchet,Fabio Del Zompo,Yuji Teraoka, Alexandre Haller,Philippe Baltzinger, Soumith Paritala,Fahmida Rasha,Naoto Fujiwara,Cloé Gadenne,Nevena Slovic,Marine A Oudot,Sarah C Durand,Clara Ponsolles,Catherine Schuster,Xiaodong Zhuang,Jacinta Holmes,Ming-Lun Yeh,Hiromi Abe-Chayama,Mathias Heikenwälder,Angelo Sangiovanni,Massimo Iavarone,Massimo Colombo,Steven K H Foung,Jane A McKeating,Irwin Davidson,Ming-Lung Yu,Raymond T Chung,Yujin Hoshida,Kazuaki Chayama,Joachim Lupberger,Thomas F Baumert

Nature Communicationsno. 1 (2024)

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The Spatial Extracellular Proteomic Tumor Microenvironment Distinguishes Molecular Subtypes of Hepatocellular Carcinoma

Jade K. Macdonald,Harrison B. Taylor,Mengjun Wang,Andrew Delacourt, Christin Edge,David N. Lewin,Naoto Kubota,Naoto Fujiwara,Fahmida Rasha,Cesia A. Marquez,Atsushi Ono,Shiro Oka,Kazuaki Chayama,Sara Lewis,Bachir Taouli,Myron Schwartz,M. Isabel Fiel,Richard R. Drake,Yujin Hoshida,Anand S. Mehta,Peggi M. Angel

Journal of Proteome Research (2024)

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Serum MYCN As a Predictive Biomarker of Prognosis and Therapeutic Response in the Prevention of Hepatocellular Carcinoma Recurrence

Xian-Yang Qin,Yohei Shirakami,Masao Honda,Shiou-Hwei Yeh,Kazushi Numata,Ya-Yun Lai,Chiao-Ling Li,Feifei Wei,Yali Xu,Kenji Imai,Koji Takai,Makoto Chuma, Nagisa Komatsu,Yutaka Furutani,Luc Gailhouste,Hiroshi Aikata,Kazuaki Chayama,Masaru Enomoto,Ryosuke Tateishi,Kazunori Kawaguchi,Tatsuya Yamashita,Shuichi Kaneko,Katsuya Nagaoka,Motohiko Tanaka,Yutaka Sasaki,Yasuhito Tanaka,Hideo Baba,Kouichi Miura,Sae Ochi,Takahiro Masaki,Soichi Kojima,Tomokazu Matsuura,Masahito Shimizu,Pei-Jer Chen,Hisataka Moriwaki,Harukazu Suzuki

INTERNATIONAL JOURNAL OF CANCERno. 3 (2024): 582-594

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Author Statistics

#Papers: 2179

#Citation: 69111

H-Index: 119

G-Index: 191

Sociability: 9

Diversity: 4

Activity: 119

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