The Mullet laboratory is researching bioenergy sorghum, a high-yielding, drought- and heat-resilient C4 grass. The sorghum genome encodes ~34,000 genes that differentially express in specific organs, tissues, and cell types during development and in response to variation in the environment. In collaboration with the Joint Genome Institute, our team is constructing a transcriptome compendium that includes gene expression profiles of every sorghum organ, tissue, and cell type, stage of development, and responses to the environment. This information is being used to identify gene regulatory networks and signaling pathways that guide plant development and mediate adaptive responses to the environment. This information is enabling the engineering of key pathways and traits using gene-editing technology.