His main research interest is optimization of antimicrobial therapy and preventing resistance emergence through application of pharmacokinetic and pharmacodynamic principles. In that area, he has (co)-authored over 200 scientific publications and book chapters, editor of several textbooks and delivered numerous (invited) lectures. He was awarded fellowship of the Infectious Diseases Society of America in 2010. From 2002-2004 he was president of the International Society Anti-infective Pharmacology (ISAP) and in 2010 one of the founding members and present secretary of the ESCMID (European Society of Clinical Microbiology and Infectious Diseases) Pharmacology of Antimicrobials Study Group (EPASG). He is present secretary of the Dutch Working Party on Antibiotic Policy, member of the expert panel of the Netherlands Veterinary Medicines Authority and also a steering committee member of the European Committee on Antimicrobial Susceptibility Testing (EUCAST).