The research in Dr. Zhang's laboratory focuses primarily on cancer biology and experimental therapeutics. In cancer biology, we are interested in regulation of gene expression and signal transduction by epigentic mechanisms and by translational control with a focus on DNA methylation and translation initiation factors. In experimental therapeutics, we are interested in multiple mechanisms of drug resistance including studies on ABC transporters, 14-3-sigma, STAT3, survivin and fatty acid synthase. We also perform drug discovery research targeting these proteins and various other known targets using chemoinformatics and rational design including repurposing FDA-approved drugs.