The lab focuses on elucidating the molecular mechanisms of innate immune signaling, especially signal transduction pathways of pyroptosis and inflammation using multi-disciplinary approaches including cryo-electron microscopy (Cryo-EM) and X-ray crystallography. The lab also studies the host-pathogen interactions by elucidating the mechanisms how pore-forming proteins/toxins recognize the specific receptors, such as sugars, lipids, and proteins on the membrane of the target cells and mediate cell death. The study will allow us to develop new therapeutic strategies against inflammasome related diseases and microbial infections. The following list shows the representative recent projects.