Jiajie Zhang’s research has spanned many areas in biomedical informatics, cognitive science, human technology integration, decision making, machine learning, and visualization. His specific research contributions are in the areas of distributed knowledge representation, usability and workflow, medical error and patient safety, and decision making. He has authored 180+ publications. He has been the principal investigator or co-investigator on numerous grants and contracts ($35 million as PI; $100 million as PI/Co-PI) from the Office of the National Coordinator for Health Information Technology (ONC), NASA, Office of Naval Research, U.S. Army, National Institutes of Health, National Science Foundation, the James S. McDonnell Foundation, the State of Texas and other funding agencies, including as PI a $15 million award for the National Center for Cognitive Informatics and Decision Making in Healthcare under ONC’s Strategic Health IT Advanced Research Projects program (SHARP) for Patient-Centered Cognitive Support.