Jeremy M. Shefner

基本信息

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职业迁徙

个人简介

He is board certified in neurology by the American Board of Psychiatry and Neurology and he specializes in ALS and neuromuscular disorders.

Dr. Shefner’s research focuses on biomarker development and the clinical therapeutics of amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy. He co-founded the Northeast ALS Clinical Trials Consortium (NEALS), the largest and most active consortium in the world dedicated to ALS. He continues to direct the NEALS outcomes and clinical monitoring cores and is currently the principal investigator for two multicenter clinical trials, as well as a biomarker study evaluating the effectiveness of electrical impedance myography in measuring ALS disease progression.

研究兴趣

论文共 358 篇作者统计合作学者相似作者

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Efficacy and Safety of Zilucoplan in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial

Sabrina Paganoni,Christina N Fournier,Eric A Macklin, Lori B Chibnik,Melanie Quintana,Benjamin R Saville,Michelle A Detry,Matteo Vestrucci,Joe Marion,Anna McGlothlin,Senda Ajroud-Driss,Marianne Chase,Lindsay Pothier, Brittney A Harkey, Hong Yu,Alexander V Sherman,Jeremy M Shefner,Meghan Hall,Gale Kittle,James D Berry,Suma Babu,Jinsy Andrews,Derek Dagostino,Eric Tustison, Elisa Giacomelli, Erica Scirocco, Gustavo Alameda,Eduardo Locatelli,Doreen Ho,Adam Quick,Jonathan Katz,Daragh Heitzman, Stanley H Appel, Sheetal Shroff,Kevin Felice,Nicholas J Maragakis,Zachary Simmons,Timothy M Miller,Nicholas Olney,Michael D Weiss,Stephen A Goutman, Joseph Americo Fernandes,Omar Jawdat,Margaret Ayo Owegi,Laura A Foster,Tuan Vu,Hristelina Ilieva,Daniel S Newman,Ximena Arcila-Londono,Carlayne E Jackson,Shafeeq Ladha,Terry Heiman-Patterson,James B Caress,Andrea Swenson,Amanda Peltier,Richard Lewis,Dominic Fee, Matthew Elliott,Richard Bedlack,Edward J Kasarskis,Lauren Elman,Jeffrey Rosenfeld,David Walk,Courtney McIlduff,Paul Twydell,Eufrosina Young, Kristin Johnson,Kourosh Rezania,Namita A Goyal,Jeffrey A Cohen,Michael Benatar, Vovanti Jones,Jonathan Glass, Jaimin Shah,Said R Beydoun,James P Wymer, Lindsay Zilliox,Shakti Nayar,Gary L Pattee,Jennifer Martinez-Thompson,Brittany Harvey, Shital Patel, Paul Mahoney,Petra W Duda, Merit E Cudkowicz, HEALEY ALS Platform Trial Study Group

JAMA network openno. 2 (2025): e2459058-e2459058

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Verdiperstat in Amyotrophic Lateral Sclerosis: Results from the Randomized HEALEY ALS Platform Trial

Writing Committee for the HEALEY ALS Platform Trial,Jinsy Andrews,Sabrina Paganoni,Eric A Macklin,Lori B Chibnik,Melanie Quintana,Benjamin R Saville,Michelle A Detry,Matteo Vestrucci, Joseph Marion,Anna McGlothlin,Eufrosina Young, Marianne Chase,Lindsay Pothier, Brittney Harkey, Hong Yu,Alex Sherman,Jeremy Shefner, Meghan Hall,Gale Kittle, Mariah R Connolly,James D Berry, Derek D'Agostino,Eric Tustison, Elisa Giacomelli, Erica Scirocco, Gustavo Alameda,Eduardo Locatelli, Doreen Ho,Adam Quick, Daragh Heitzman,Senda Ajroud-Driss, Stanley H Appel, Sheetal Shroff,Jonathan Katz, Kevin Felice,Nicholas J Maragakis,Zachary Simmons,Stephen A Goutman,Nicholas Olney,Timothy Miller, Joseph Americo Fernandes,Hristelina Ilieva,Omar Jawdat,Michael D Weiss, Laura Foster, Tuan Vu,Shafeeq Ladha, Margaret Ayo Owegi, Daniel S Newman,Ximena Arcila-Londono, Carlayne E Jackson,Andrea Swenson,Terry Heiman-Patterson, James Caress,Dominic Fee,Amanda Peltier,Richard Lewis,Jeffrey Rosenfeld,David Walk, Kristin Johnson, Matthew Elliott,Edward J Kasarskis,Seward Rutkove,Courtney E McIlduff,Richard Bedlack,Lauren Elman, Namita A Goyal,Kourosh Rezania, Paul Twydell,Michael Benatar, Jonathan Glass,Jeffrey A Cohen, Vovanti Jones, Lindsay Zilliox, James P Wymer, Said R Beydoun, Jaimin Shah, Gary L Pattee, Jennifer Martinez-Thompson, Shakti Nayar,Volkan Granit, Mary Donohue, Katheryn Grossman, Daniel J Campbell,Irfan A Qureshi, Merit E Cudkowicz,Suma Babu

JAMA neurologyno. 4 (2025): 333-343

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CNM-Au8 in Amyotrophic Lateral Sclerosis: the HEALEY ALS Platform Trial

Writing Committee for the HEALEY ALS Platform Trial,James D Berry,Nicholas J Maragakis,Eric A Macklin,Lori B Chibnik,Melanie Quintana,Benjamin R Saville,Michelle A Detry,Matteo Vestrucci, Joseph Marion,Anna McGlothlin,Elijah W Stommel, Marianne Chase,Lindsay Pothier, Brittney A Harkey, Hong Yu,Alex Sherman,Jeremy Shefner, Meghan Hall,Gale Kittle,Suma Babu,Jinsy Andrews, Derek D'Agostino,Eric Tustison, Erica Scirocco,Elisa Giacomelli, Gustavo Alameda,Eduardo Locatelli, Doreen Ho,Adam Quick,Senda Ajroud-Driss,Jonathan Katz, Daragh Heitzman, Stanley H Appel, Sheetal Shroff, Kevin J Felice,Zachary Simmons,Timothy Miller,Nicholas Olney,Michael D Weiss,Stephen A Goutman, Joseph Americo Fernandes,Omar Jawdat, Margaret Ayo Owegi, Laura Foster, Tuan Vu,Hristelina Ilieva, Daniel S Newman,Ximena Arcila-Londono,Carlayne Jackson,Shafeeq Ladha,Terry Heiman-Patterson, James Caress,Andrea Swenson,Amanda Peltier,Richard Lewis,Dominic Fee, Matthew Elliott,Richard Bedlack,Edward J Kasarskis,Lauren Elman,Jeffrey Rosenfeld,David Walk, Courtney E McIlduff, Paul Twydell,Eufrosina Young, Kristin Johnson,Kourosh Rezania, Namita A Goyal,Jeffrey A Cohen,Michael Benatar, Vovanti Jones, Jonathan Glass, Jaimin Shah, Said R Beydoun, James P Wymer, Lindsay Zilliox, Shakti Nayar, Gary L Pattee, Jennifer Martinez-Thompson,Austin Rynders, Jacob Evan, Jeremy Evan, Alan Hartford, Marjan Sepassi, Karen S Ho,Robert Glanzman,Benjamin Greenberg, Michael T Hotchkin,Sabrina Paganoni, Merit E Cudkowicz, HEALEY ALS Platform Trial Study Group

pubmed（2025）

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Pridopidine in Amyotrophic Lateral Sclerosis: the HEALEY ALS Platform Trial

Writing Committee for the HEALEY ALS Platform Trial,Jeremy M Shefner,Björn Oskarsson,Eric A Macklin,Lori B Chibnik,Melanie Quintana,Benjamin R Saville,Michelle A Detry,Matteo Vestrucci, Joe Marion,Anna McGlothlin,Terry Heiman-Patterson, Marianne Chase,Lindsay Pothier, Brittney A Harkey, Hong Yu, Alexander V Sherman, Meghan Hall,Gale Kittle,James D Berry,Suma Babu,Jinsy Andrews, Derek D'Agostino,Eric Tustison, Erica Scirocco,Elisa Giacomelli, Gustavo Alameda,Eduardo Locatelli, Doreen Ho,Adam Quick,Senda Ajroud-Driss,Jonathan Katz, Daragh Heitzman, Stanley H Appel, Sheetal Shroff, Kevin Felice,Nicholas J Maragakis,Zachary Simmons,Timothy M Miller,Nicholas Olney,Michael D Weiss,Stephen A Goutman, Joseph Americo Fernandes,Omar Jawdat, Margaret Ayo Owegi, Laura A Foster, Tuan Vu,Hristelina Ilieva, Daniel S Newman,Ximena Arcila-Londono, Carlayne E Jackson,Shafeeq Ladha,James B Caress,Andrea Swenson,Amanda Peltier,Richard A Lewis,Dominic Fee, Matthew Elliott,Richard Bedlack,Edward J Kasarskis,Lauren Elman,Jeffrey Rosenfeld,David Walk,Courtney McIlduff, Paul Twydell,Eufrosina Young, Kristin Johnson,Kourosh Rezania, Namita A Goyal,Jeffrey A Cohen,Michael Benatar, Vovanti Jones, Jaimin Shah, Said R Beydoun, James P Wymer, Lindsay Zilliox, Shakti Nayar, Gary L Pattee, Jennifer Martinez-Thompson, Melanie L Leitner, Kelly Chen,Y Paul Goldberg,Yael Cohen,Michal Geva,Michael R Hayden,Sabrina Paganoni, Merit E Cudkowicz, HEALEY ALS Platform Trial Study Group

pubmed（2025）

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Guidance for Clinical Management of Pathogenic Variant Carriers at Elevated Genetic Risk for ALS/FTD

Michael Benatar,Terry D Heiman-Patterson,Johnathan Cooper-Knock, Daniel Brickman, Kaitlin B Casaletto,Stephen A Goutman, Marco Vinceti,Laynie Dratch,Jalayne J Arias, Jean Swidler,Martin R Turner,Jeremy Shefner,Henk-Jan Westeneng,Leonard H van den Berg,Ammar Al-Chalabi

Journal of neurology, neurosurgery, and psychiatry（2025）

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Reldesemtiv in Amyotrophic Lateral Sclerosis: Results from the COURAGE-ALS Randomized Clinical Trial

Jeremy M Shefner, Merit E Cudkowicz,Angela Genge,Orla Hardiman,Ammar Al-Chalabi,Jinsy A Andrews,Adriano Chio,Philippe Corcia, Philippe Couratier,Mamede de Carvalho,Terry Heiman-Patterson,Robert D Henderson,Caroline Ingre,Wendy Johnston,Albert Ludolph,Nicholas J Maragakis,Timothy M Miller, Jesus S Mora,Susanne Petri,Zachary Simmons,Leonard H van den Berg,Lorne Zinman,Stuart Kupfer,Fady I Malik,Lisa Meng, Tyrell J Simkins,Jenny Wei, Andrew A Wolff,Stacy A Rudnicki, COURAGE-ALS Study Group

JAMA neurology（2025）

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Operational Development and Launch of an Adaptive Platform Trial in Amyotrophic Lateral Sclerosis: Processes and Learnings from the First Four Regimens of the HEALEY ALS Platform Trial

Brittney A Harkey, Sofia Distefano, Jaclyn A Pagliaro, Lindsay Heyd, Marianne Chase, Courtney Igne, Hong Yu, Alexander V Sherman, Derek Dagostino,Eric Tustison, Genevive Changkuon, Meghan Hall,Gale Kittle, Mariah R Connolly, Elisa Giacomelli, Erica Scirocco,James D Berry,Suma Babu,Jeremy Shefner, Eric A Macklin, Lori B Chibnik, Annette De Mattos, Kristin Drake,Cornelia Kamp,Andrew McGarry,Margherita Torti, Catherine Small, Allison Bulat, Merit E Cudkowicz,Sabrina Paganoni, HEALEY ALS Platform Trial Study Group

Muscle & nerve (2025)

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Akt Activation with IPL344 Treatment for Amyotrophic Lateral Sclerosis: First in Human, Open-Label Study

Marc Gotkine, David A Schoenfeld, Ilana Cohen,Jeremy M Shefner, Yossef Lerner,Irun R Cohen, Colin Klein, Eran Ovadia, Merit E Cudkowicz, Pooled Resource Open‐Access ALS Clinical Trials Consortium

Muscle & nerveno. 6 (2025): 1032-1042

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Access for ALL in ALS: A Large-Scale, Inclusive, Collaborative Consortium to Unlock the Molecular and Genetic Mechanisms of Amyotrophic Lateral Sclerosis