Dr. Wefel is a board certified neuropsychologist, Professor with Tenure, and Neuropsychology Section Chief in the Department of Neuro -Oncology. He maintains an active consultation-liaison service where he conducts comprehensive neuropsychological assessments, presurgical fMRI of higher order cognitive function for neurosurgical planning, and offers interventions to adult cancer patients suffering from the central nervous system effects of cancer, cancer treatment, or other illnesses. He provides clinical and research mentoring as a Program Supervisor within the Neuropsychology Postdoctoral Fellowship program and hold an appointment as an Adjunct Clinical Assistant Professor in the Clinical Psychology graduate program at the University of Houston where he is involved in the training of Neuropsychology graduate students. Dr. Wefel's research activities seek to characterize the prevalence, pattern, course, risks, and biologic and neural substrates for the development of neurocognitive dysfunction associated with cancer and cancer therapies. Ultimately, this will lead to identification and testing of interventions to prevent and/or minimize cognitive dysfunction. He is the neurocognitive study chair on numerous cooperative group, industry sponsored and investigator initiated trials involving patients with breast cancer, brain tumor and brain metastasis, many of which integrate cognitive and neuroimaging outcomes as well as exploration of genetic moderators of cognitive and brain outcomes.