Dr. Coller has joint appointments in both the Biology department, as well as the Molecular Biology & Genetics department at the School of Medicine. Now we study how regulation is built into this system by looking at 1] how the mRNA degradation machinery interacts with the ribosome 2] how features such as RNA modifications can impact codon optimality and 3] how tRNA biology can ultimately impact mRNA levels. Lastly, we are harnessing these discoveries, pushing open this exciting field, and leveraging our findings towards the development of novel therapeutics.