I am interested in the neuropathology and pathophysiology of neurodegeneration, in particular motor neurone disease (MND), Parkinson’s disease and dementia. I use standard neuropathological techniques to characterise post mortem tissue kindly donated by individuals with these diseases and to highlight contrasts with tissue from people who were free from disease. These methods are used to study genes, proteins and molecular pathways of interest and the pathological effects of gene mutations known to neurodegeneration. I study mouse, zebrafish and cellular models of disease and the comparison of these with human tissue based pathology. The pathobiology and neuropathology of C9ORF72-mediated MND Oligodendrocyte disease and function in MND TIGAR-related pathology in Parkinson’s disease Zebrafish models of Parkinson’s disease The relationship between pathological and radiological measures of white matter in vascular dementia.