My research focuses on the chemistry and biology of microbial natural products. This encompasses natural product discovery, elucidation of biosynthetic pathways, creation of natural product analogues and novel molecular scaffolds via synthetic biology, and the mechanism of action and biological function of natural products. Our approach is highly interdisciplinary and employs numerous complementary techniques, including chemical synthesis and analysis, molecular genetic manipulation, enzymology, protein mass spectrometry, structural biology (X-ray crystallography, protein NMR spectroscopy and single particle cryo-electron microscopy), bioinformatics, molecular modelling, and bioactivity assays.