His laboratory focuses on the structural characterization of membrane-associated processes and those carried out by transient soluble assemblies using electron cryo-microscopy approaches. The work includes both development of computational methods (e.g., cryo subtomogram analysis, integrative modeling) and experimental studies ranging from isolated protein complexes to whole cells. A strong basis on physics and computation allows us to address structural biology questions from unusual angles at the interface of molecular and cellular structural biology. Main biological interests include a molecular understanding of the biogenesis of proteins at organelle membranes studies and its regulation in health and disease.