Research in the lab is currently focusing on enteroendocrine cells, especially glucagon-like peptide-1 (GLP-1) secreting cells, which we hope to target in the treatment of diabetes and obesity. GLP-1 secreting cells are electrically excitable and respond to changes in ambient nutrient supply through electrogenic uptake and an increase in action potential firing frequency. We also started to work on GLP-1 target cells including enteric and affarent autonomic neurons. In addition we have a longstanding interest in nociception, characterising ion channel mutations found by Geoff Woods group in inherited pain disorders.