His principal research interest and key discoveries have been focused on several specific areas: (i) epigenetic changes in hemato-oncological patients, mainly multiple myeloma and leukemia-MDS; (ii) identification of new epigenetic targets and design of new molecules; (iii) stem cell biology and stem cell therapy for human diseases; (iv) clinical trials in patients with multiple myeloma and leukemia-MDS. Professor Prosper has published more than 400 peer review articles in top journals including New England Journal of Medicine, Nature Genetics, Blood, Journal of Clinical Oncology, Journal of Clinical Investigation, Leukemia, Genome Research or Oncogene among others with an H-factor of 55 and over 10.000 citations and has given more than 400 lectures. His laboratory is funded through national and international grants including competitive programs such as IMF, European Union (FP6, FP7 and H2020), Spanish Ministry of Health and Ministry of Science and has obtained more than 50 grants. He has received multiple awards and prizes and has mentored over 30 PhD students and postdocs during his career.