We study the genetic underpinnings of specific diseases; eg. how genetic mutations translate into tubular structure malformation, vascular integrity collapse, or neural dysfunction. Within this, our lab has two main focuses: 1. Notch signaling deregulation in Alagille syndrome, and Notch control of biliary and vascular development therein. 2. Development of ultrasound-guided in utero nanoinjection as a powerful tool to manipulate gene expression in specific organs during development.