We develop and use a variety of biophysical methods to characterise the interactions of biological macromolecules in solution and in the cell. These include proteins (soluble and membrane bound), protein/DNA complexes and nanoparticles. We have expertise in analytical ultracentrifugation, calorimetry, structural methods and various spectroscopies. We collaborate widely both nationally and internationally, and are actively involved in the University Nottingham BBSRC DTP and the MRC IMPACT DTP, with students from both schemes placed in our group.