Fundamentally Dave interest in science revolves around the conundrum of structure-function relationships. Historically, he has used mass spectrometry to pursue this interest and recently, which led to involvement in the investigation of early protein markers of lung diseases and leukemia classification as well as use of chemical cross-linking to ascertain juxtaposed faces of interacting proteins. Additionally, the structure-function relationship of immunologically active lipids pertinent to human health and disease are being investigated using mass spectrometry. All of these efforts are supported by several burgeoning technology projects in mass spectrometry and microfluidics, as well as software development to support structure analysis and omic pipelines. The discovery based science projects within the laboratory are used to generate hypotheses complementary to those generated by literature review in support of our medical and biological collaborators. In general we take an indolent driven approach to experimentation that seeks parsimony in data acquisition and interpretation. All of my graduate students have a co-mentor whose biomedical problem we develop novel methods to solve.