Recently his research and development has focused on nanoparticles, again for anti-cancer applications. Recognizing that cancers are known to “feed” on Low Density Lipoprotein (LDL) particles (--sub microscopic nanoparticles composed of fat and protein) from the blood stream, his new strategy is to “make the drug look like the cancer’s food”. The new technology turns the low solubility “bricks” of the pharmaceutical industry, that are very difficult to administer in effective doses by oral tablets, and turns them into much less soluble “rocks” so that they can be made into the LDL-sized nanoparticles for intravenous delivery. This work is in close collaboration with his colleague, Dave Gooden PhD, Director of the Duke Small Molecule Synthesis Facility; hence their “Bricks-to-Rocks Technology (B2RT). Here, in collaboration, with Will Eward DVM, MD Dept of Surgical Oncology and Ivan Spasojevic, PhD, Director of the PK/PD core, they have pioneered testing this new kind of anti-cancer drug nanoparticle. It has already shown positive results in a lung-metastatic mouse model of Osteosarcoma, as well as in a recent feasibility trial in canine patients with Steve Suter VMD, MS, PhD, DACVIM and colleagues at the NC State Veterinary School.