While he serves as a senior methodologist within his primary Department, which has provided a diversity of research involvements across the spectrum of ophthalmic diseases, his research has focused on corneal transplantation outcomes, clinical trials of treatments for glaucoma, and best practices for the screening and care of prevalent childhood eye diseases.

Dr. Musch was appointed as a Fellow of the American College of Epidemiology in 1997, a Fellow of the Association for Research in Vision and Ophthalmology in 2009, and a Fellow of the American Association for the Advancement of Science in 2021. He has received multiple awards for his service to the American Academy of Ophthalmology (AAO), including its Honor Award (1990), Secretariat Award (2003, 2006, & 2013), its Senior Achievement Award (2006), and its Life Achievement Award (2020). He received the Lew R. Wasserman Merit Award from Research to Prevent Blindness, New York, NY in 2009.