Dr. Talan is considered an authority in the area of acute infections that result in severe morbidity and death. His research focuses on emergency department-based surveillance and epidemiological research of emerging infections and clinical investigations of acute infectious diseases. He has investigated skin and soft tissue infections, animal and human bites, rabies, tetanus, pneumonia, pyelonephritis, meningitis, bacterial antibiotic resistance, and sepsis. He was PI of an NIH contract to study off-patent antibiotics to treat skin infections caused by MRSA called STOP MRSA. This project led to NEJM and JAMA publications, which resulted in practice changes for treatment of skin abscess and cellulitis.