In the ”˜90s he returned to Milan at San Raffaele where he directed the Bone Marrow Transplantation Program, and founded and led the group that performed the first worldwide experience of gene therapy in hematopoietic stem cells for hereditary diseases. In 2002 this work led to the publication of the first successful gene therapy treatment of adenosine deaminase-deficient SCID. He expanded this experience to stem cell gene therapy of other genetic diseases and AIDS, and to immuno-gene therapy of cancer. Dr. Bordignon has been President of European Society of Genetic Therapy and Member of major Scientific Committees. Presently, he is Chairman&CEO of MolMed S.p.A., a biotech company dedicated to the development of new anti-cancer molecular treatments. He contributed to its foundation in 1996. In July 2005, he was also appointed by the European Commission as one of the 22 eminent founding members of the Scientific Council of the European Research Council (ERC). He received numerous scientific awards and prizes from scientific societies including the Italian Association for Cancer Research, the Leukemia Society of America, the European Society for Gene Therapy, the Italian League Against Tumors. In 2002 he was awarded the Invernizzi Prize for Medicine, the most important medical award in Italy.