Carlo Donadio

Graduated in Medicine cum laude in 1972. Post-graduated in Internal Medicine (1977), Nephrology (1980), Nuclear Medicine (1984) cum laude. Researcher in Biochemistry from 1975 to 1977 Researcher in Internal Medicine from 1977 to 1991 Associate Professor of Nephrology from 1991. Scientific activity: Validation of 99mTc-DTPA as a reliable marker for the measurement of glomerular filtration rate in man. Prediction of creatinine clearance and of GFR from plasma creatinine concentration and body composition analysis. A new method for the measurement of divided renal function and for the diagnosis of renovascular hypertension. Aprotinin labelled with Tc99m: a new tracer for renal scintigraphy. Evaluation of the renal handling of low molecular weight proteins; studies in man and in animals. Evaluation of serum and urinary markers of renal function and nephrotoxicity. New plasmatic indicators for glomerular filtration rate: tumor associated trypsin inhibitor (TATI), cystatin C, beta-trace protein, chromogranin. Nephrotoxicity due to low- and high-osmolar contrast media. Comparison of the usefulness of different urinary indicators for the evaluation of the nephrotoxicity. Prevention of nephrotoxicity due to cis-platin in high risk patients. Dose individualization to minimize nephrotoxicity due to carbo-platin. Morphological and functional alteration in patients affected by ovarian cancer. Renal morphology and functional evaluation of potential kidney living donors. Evaluation of renal graft morphology and function. Tubular dysfunction in kidney grafts. Analysis of body composition and of body compartments in adult and children with chronic renal disease (CKD). Evaluation of malnutrition in CKD, maintenance hemodialysed, and transplanted patients. Cardiovascular risk in chronic kidney disease. Parathyroid hormone and large related C-terminal fragments increase at different rates with worsening of renal function in chronic kidney disease patients. A possible indicator of bone turnover status In vivo and in vitro effects of simvastatin on inflammatory markers in pre-dialysis patients. Proteomic analysis of depurative carachreristics and effects on inflammatory markers of resins and membranes for hemodialysis. Patho-physiology of uremic syndrome: fragmentation of albumin in the serum of maintenance hemodialysis patients evaluated by means of proteomic analysis. Screening of early GFR impairment by means of urinay excretion of Beta-trace protein in CKD Patients.