Charles E. De Bock - Queensland Institute of Medical Research

基本信息

Career Trajectory

Bio

I am a trained cellular and molecular biologist and fascinated by cancer biology. My research interests have focussed on how specific genetic aberrations in cancer either act alone or cooperate with one another to aid in cancer onset and progression. I am also interested in biomarker and cancer specific target discovery. Currently my research is focused on genetic changes in acute lymphoblastic leukemia for which I use both in vitro cell culture and in vivo bone marrow transplant models.

Research Interests

Papers共 121 篇Author StatisticsCo-AuthorSimilar Experts

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FAT1 Functions As an Oncogenic Driver in Triple Negative Breast Cancer Through AKT Pathway-Driven Effects on the Matrisome

Panpan Zhao,Yuanyuan Zhang,Yang Yu,Qing Zhang,Xiaoying Liu,Xu Dong Zhang,Song Chen,Charles E de Bock,Rick F Thorne, Yujie Shi

International journal of biological sciencesno. 5 (2025): 2201-2222

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Mastering Fate: Redistributing a Pioneer Protein to Rewrite Leukemia's Script

Yizhou Huang,Charles E de Bock

HemaSphereno. 1 (2025): n/a-n/a

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TLE4 is a Repressor of the Oncogenic Activity of TLX3 in T-cell Acute Lymphoblastic Leukemia

Lukas Lauwereins,Quentin Van Thillo,Sofie Demeyer,Nicole Mentens,Sarah Provost, Kris Jacobs,Olga Gielen, Lien Boogaerts,Charles E. de Bock, Guillaume Andrieu,Vahid Asnafi,Jan Cools,Alexandra Veloso

Leukemia（2025）

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A New Mouse Model Highlights the Need for Better JAK Inhibitors in Myeloproliferative Neoplasms

Charles E. de Bock

HemaSphere（2024）

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A novel MYB::PAIP1 oncogenic fusion in pediatric blastic plasmacytoid dendritic cell neoplasm (BPDCN) is dependent on BCL2 expression and is sensitive to venetoclax

Hansen J. Kosasih, Gerry Healey,Margs S. Brennan,Stefan Bjelosevic,Teresa Sadras,Fatimah B. Jalud,Tasnia Ibnat,Ashley P. Ng,Chelsea Mayoh, Jie Mao,Gabor Tax,Louise E. A. Ludlow,Ricky W. Johnstone,Marco J. Herold,Seong L. Khaw,Charles E. de Bock,Paul G. Ekert

HemaSphere（2024）

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PU.1 Eviction at Lymphocyte-Specific Chromatin Domains Mediates Glucocorticoid Response in Acute Lymphoblastic Leukemia

Dominik Beck, Honghui Cao, Feng Tian,Yizhou Huang, Miao Jiang, Han Zhao,Xiaolu Tai,Wenqian Xu,Hansen J. Kosasih,David J. Kealy, Weiye Zhao, Samuel J. Taylor, Timothy A. Couttas, Gaoxian Song,Diego Chacon-Fajardo, Yashna Walia, Meng Wang,Adam A. Dowle,Andrew N. Holding,Katherine S. Bridge,Chao Zhang,Jin Wang,Jian-Qing Mi,Richard B. Lock,Charles E. de Bock,Duohui Jing

NATURE COMMUNICATIONSno. 1 (2024)

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A Novel MYB::PAIP1 Oncogenic Fusion in Pediatric Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) is Dependent on BCL2 Expression and is Sensitive to Venetoclax

Hansen J. Kosasih, Gerry Healey,Margs S. Brennan,Stefan Bjelosevic,Teresa Sadras, Fatimah B. Jalud,Tasnia Ibnat,Ashley P. Ng,Chelsea Mayoh, Jie Mao,Gabor Tax,Louise E. A. Ludlow,Ricky W. Johnstone,Marco J. Herold,Seong L. Khaw,Charles E. de Bock,Paul G. Ekert

HemaSphere（2024）

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Selective Targeting of Malignant T Cells

Charles E. de Bock,Jan Cools

NATURE CANCERno. 6 (2024): 823-824

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