Our lab has developed and studies a transgenerational social stress based rodent model of postpartum depression/anxiety. Current animal research includes the impact of social stress and air pollution on behavior, immune factors, neural connectivity, neuroendocrinology, and related epigenetic changes. Ongoing clinical work explores the role of behavioral hormones, discrimination, and epigenetic changes in postpartum depression/anxiety. We are also using fMRI to identify the neural correlates of mindfulness based stress reduction as part of a stage IIa randomized clinical trial, and fMRI data combined with related clinical measures to develop early predictors of severe depression and suicidality.