Andrew G. Cole - Princeton Public Schools

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论文共 81 篇作者统计合作学者相似作者

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Structure-Activity Relationships and Discovery of (S)-6-isopropyl-2-methoxy-3-(3-methoxypropoxy)-10-oxo-5,10-dihydr O-6H-pyrido[1,2-h][1,7]naphthyridine-9-carboxylic Acid (AB-452), a Novel Orally Available HBV RNA Destabilizer

Dimitar Gotchev,Bruce D. Dorsey,Duyan Nguyen,Ramesh Kakarla,Benjamin Dugan,Shuai Chen,Min Gao,Lauren Bailey,Fei Liu,Troy Harasym,Tim Chiu,Sunny Tang,Amy C. -H. Lee,Andrew G. Cole,Michael J. Sofia

Journal of Medicinal Chemistryno. 2 (2024): 1421-1446

引用2浏览0WOS引用

Rational Design, Synthesis, and Structure–Activity Relationship of a Novel Isoquinolinone-Based Series of HBV Capsid Assembly Modulators Leading to the Identification of Clinical Candidate AB-836

Andrew G. Cole,Steven G. Kultgen,Nagraj Mani,Kristi Yi Fan,Andrzej Ardzinski,Kim Stever,Bruce D. Dorsey,Eugen F. Mesaros,Emily P. Thi,Ingrid Graves,Sunny Tang,Troy O. Harasym,Amy C. H. Lee,Andrea Olland,Robert K. Suto,Michael J. Sofia

Journal of Medicinal Chemistry (2024)

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Discovery of C-Linked Nucleoside Analogues with Antiviral Activity Against SARS-CoV-2

Eugen F. Mesaros,Benjamin J. Dugan,Min Gao,Muhammad Sheraz, Kayleigh McGovern-Gooch, Fran Xu,Kristi Yi Fan,Duyan Nguyen,Steven G. Kultgen, Aaron Lindstrom,Kim Stever, Breanna Tercero, Randall J. Binder,Fei Liu,Holly M. Micolochick Steuer,Nagraj Mani,Troy O. Harasym,Emily P. Thi,Andrea Cuconati,Bruce D. Dorsey,Andrew G. Cole,Angela M. Lam,Michael J. Sofia

ACS INFECTIOUS DISEASES（2024）

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Conformationally Constrained Isoquinolinones As Orally Efficacious Hepatitis B Capsid Assembly Modulators

Eugen F. Mesaros,Andrew G. Cole,Steven G. Kultgen,Nagraj Mani,Kristi Yi Fan,Benjamin J. Dugan,Andrzej Ardzinski,Kim Stever,Holly M. Micolochick Steuer,Ingrid Graves,Sunny Tang,Troy O. Harasym,Angela M. Lam,Emily P. Thi,Bruce D. Dorsey,Michael J. Sofia

ACS MEDICINAL CHEMISTRY LETTERSno. 9 (2024): 1627-1634

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Biological Characterization of Ab-343, a Novel and Potent Sars-Cov-2 Mpro Inhibitor with Pan-Coronavirus Activity

Kayleigh R. McGovern-Gooch,Nagraj Mani,Dimitar Gotchev,Andrzej Ardzinski,Rose Kowalski,Muhammad Sheraz,Holly M. Micolochick Steuer, Breanna Tercero,Xiaohe Wang, Adam Wasserman, Konstanze von Konig,Klaus Maskos, Archna Prasad,Michael Blaesse, Andreas Bergmann, Debora L. Konz Makino,Kristi Y. Fan,Steven G. Kultgen, Aaron Lindstrom,Duyan Nguyen, Marvin Vega,Xu Wang,Nicole Bracci,Susan R. Weiss,Andrew G. Cole,Angela M. Lam,Andrea Cuconati,Michael J. Sofia

ANTIVIRAL RESEARCH (2024)

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Structure-Activity Relationships and Discovery of (S)-5-(tert-butyl)-11-(difluoromethoxy)-9-methoxy-2-oxo-1, 2,5,6-Tetrahydropyrido[2′,1′:2,3]Imidazo[4,5-h]quinoline-3-carbox Ylic Acid (AB-161), a Novel Orally Available and Liver-Centric HBV RNA Destabilizer

Dimitar Gotchev, Shuai Chen,Benjamin Dugan,Bruce D. Dorsey, Xu Wang,Muhammad Sheraz,Rose Kowalski,Fei Liu,Sunny Tang,Tim Chiu,Troy Harasym,Ingrid E. Graves,Emily P. Thi, Jeremy D. Mason, Nathan Overholt, Ravi Dugyala,Angela M. Lam,Andrew G. Cole,Michael J. Sofia

JOURNAL OF MEDICINAL CHEMISTRYno. 22 (2024): 20467-20494

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Rational Design of Macrocyclic Noncovalent Inhibitors of SARS-CoV-2 Mpro from a DNA-Encoded Chemical Library Screening Hit That Demonstrate Potent Inhibition Against Pan-Coronavirus Homologues and Nirmatrelvir-Resistant Variants

Xu Wang,Dimitar Gotchev,Kristi Yi Fan, Marvin M. Vega,Nagraj Mani, Kayleigh McGovern-Gooch,Andrea Cuconati, Breanna Tercero,Xiaohe Wang, Philip Carpino,Klaus Maskos,Paolo A. Centrella, Andreas Schmitt, Franziska Preuss, Archna Prasad, Chia-yi Chen,Matthew A. Clark,John P. Guilinger, Shawn Johnstone, Konstanze von Konig,Anthony D. Keefe, Jenny Liu, Stephane Turcotte,Ying Zhang, Debora L. Konz Makino,Angela M. Lam,Andrew G. Cole,Michael J. Sofia

JOURNAL OF MEDICINAL CHEMISTRY（2024）

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Preclinical Antiviral and Safety Profiling of the HBV RNA Destabilizer AB-161

Angela M. Lam, Ravi R. Dugyala, Muhammed Sheraz,Fei Liu,Emily P. Thi,Ingrid E. Graves,Andrea Cuconati,Holly Micolochick Steuer,Andrzej Ardzinski, Nathan Overholt, Jeremy D. Mason,Dimitar Gotchev,Andrew G. Cole,Troy O. Harasym,Michael J. Sofia

VIRUSES-BASELno. 3 (2024)

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Design, Synthesis, and Structure-Activity Relationship of a Bicyclic HBV Capsid Assembly Modulator Chemotype Leading to the Identification of Clinical Candidate AB-506

Andrew G. Cole,Steven G. Kultgen,Nagraj Mani,Jorge G. Quintero,Kristi Yi Fan,Andrzej Ardzinski,Kim Stever,Bruce D. Dorsey,Janet R. Phelps,Amy C. H. Lee,Emily P. Thi,Tim Chiu,Sunny Tang,Peter S. Horanyi,Stephen J. Mayclin,Troy O. Harasym,Michael J. Sofia

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2023)

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